About Gene List

PF3D7_1332200

Genome location: Pf3D7_13_v3:1,332,221..1,335,647(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020007 apical complex
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.09 0.95
Trophozoite possibly expressed 0.05 0.98
Schizont expressed 1.32 0.55
Gametocyte possibly expressed 0.07 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1332200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.996 | MFS: -0.983 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1347000)

Modification: Tagged | RMgm-4949

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8U2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533417

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 54 29 78
disruptive 38 156 64 157
missense 36 151 60 150

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 19 98 52 86
disruptive 60 258 111 220
missense 54 240 105 175

PlasmoDB Total SNPs: 144

Non-coding: 74 | Synonymous: 30 | Nonsynonymous: 40 | Stop Codon: 0

Protein Information

Protein Length: 1001 | Molecular Weight (kDa): 113.555

UniProt ID(s): A0A5K1K8U2

PDB ID(s): None

Isoelectric Point: 9.82

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
33705380 Molecular characterization of the conoid complex in Toxoplasma reveals itsconservation in all apicomplexans, including Plasmodium species. Koreny L, Zeeshan M, ..., Waller RF 10.1371/journal.pbio.3001081