Genome location: Pf3D7_13_v3:1,335,713..1,337,184(+)
Genome classification: Core
Product Description: trafficking protein particle complex subunit 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0030008 | TRAPP complex |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.17 | 0.91 |
| Trophozoite | expressed | 0.43 | 0.74 |
| Schizont | expressed | 0.22 | 0.86 |
| Gametocyte | expressed | 0.26 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1332300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.175 | MFS: -2.789 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IE05
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102292
Most Similar Human Ortholog: P0DI82
TM-align score: 0.92 | RMSD: 1.59
Seq Identity: 0.42 | Length: 137 / 163
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000196459 | trafficking protein particle complex 2 |
| ENSG00000256060 | trafficking protein particle complex 2B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 8 | 3 | 11 |
| disruptive | 1 | 6 | 7 | 16 |
| missense | 1 | 6 | 6 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 17 | 7 | 15 |
| disruptive | 3 | 15 | 12 | 37 |
| missense | 2 | 13 | 8 | 25 |
PlasmoDB Total SNPs: 113
Non-coding: 108 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 163 | Molecular Weight (kDa): 18.565
UniProt ID(s): Q8IE05
PDB ID(s): None
Isoelectric Point: 6.6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006722 | Trafficking protein particle complex subunit 2 |
| InterPro | IPR011012 | Longin-like domain superfamily |
| PFam | PF04628 | Trafficking protein particle complex subunit 2 |
| Superfamily | SSF64356 | Longin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 24086721 | Comparative genomic analysis of multi-subunit tethering complexes demonstrates anancient pan-eukaryotic complement and sculpting in Apicomplexa. | Klinger CM, Klute MJ, Dacks JB | 10.1371/journal.pone.0076278 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |