PF3D7_1332800

Genome location: Pf3D7_13_v3:1,347,359..1,349,852(+)

Genome classification: Core

Function and Localization

Product Description: eukaryotic translation initiation factor 6, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol
Component	GO:0005730	nucleolus
Component	GO:0005634	nucleus
Component	GO:0030687	preribosome, large subunit precursor
Function	GO:0043023	ribosomal large subunit binding
Process	GO:1902626	assembly of large subunit precursor of preribosome
Process	GO:0000460	maturation of 5.8S rRNA
Process	GO:0000470	maturation of LSU-rRNA
Process	GO:0042273	ribosomal large subunit biogenesis
Process	GO:0000054	ribosomal subunit export from nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.08	0.96
Trophozoite	expressed	0.09	0.94
Schizont	expressed	0.01	0.99
Gametocyte	expressed	0.14	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1332800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.961 | MFS: -2.873 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE00

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101255

Most Similar Human Ortholog: B7ZBH1

TM-align score: 0.97 | RMSD: 0.79

Seq Identity: 0.64 | Length: 108 / 247

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000242372	eukaryotic translation initiation factor 6

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	10	5	22
disruptive	1	2	3	12
missense	1	2	3	10

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	25	8	20
disruptive	2	9	4	44
missense	1	8	4	31

PlasmoDB Total SNPs: 80

Non-coding: 71 | Synonymous: 8 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 247 | Molecular Weight (kDa): 27.25

UniProt ID(s): Q8IE00

PDB ID(s): None

Isoelectric Point: 4.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002769	Translation initiation factor IF6
PFam	PF01912	Translation initiation factor IF6
Superfamily	SSF55909	N/A