PF3D7_1333300

Genome location: Pf3D7_13_v3:1,367,637..1,369,621(-)

Genome classification: Core

Function and Localization

Product Description: transmembrane emp24 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030134	COPII-coated ER to Golgi transport vesicle
Component	GO:0005794	Golgi apparatus
Component	GO:0005783	endoplasmic reticulum
Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
Component	GO:0016020	membrane
Function	GO:0003723	RNA binding
Function	GO:0008320	protein transmembrane transporter activity
Process	GO:0007030	Golgi organization
Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport
Process	GO:0006886	intracellular protein transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.06	0.97
Trophozoite	possibly expressed	0.14	0.91
Schizont	possibly expressed	0.06	0.96
Gametocyte	possibly expressed	0.07	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1333300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.93 | MFS: -2.947 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1348000)

Relative Growth Rate: 0.99 ± 0.08
Confidence: 6.41

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1348000)

Modification: Disrupted | RMgm-3631

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDZ5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101611

Most Similar Human Ortholog: P49755

TM-align score: 0.72 | RMSD: 3.45

Seq Identity: 0.18 | Length: 195 / 211

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000170348	transmembrane p24 trafficking protein 10

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	rare	singleton
synonymous	1	0
disruptive	0	1
missense	0	0

PlasmoDB Total SNPs: 102

Non-coding: 96 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 211 | Molecular Weight (kDa): 24.995

UniProt ID(s): Q8IDZ5

PDB ID(s): None

Isoelectric Point: 9.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009038	GOLD domain
InterPro	IPR015720	TMP21-related
PFam	PF01105	GOLD domain
Superfamily	N/A	N/A