PF3D7_1333400

Genome location: Pf3D7_13_v3:1,369,452..1,370,905(+)

Genome classification: Core

Function and Localization

Product Description: AMMECR1 domain-containing protein, putative

SignalP Peptide: MIRKRVELQFFLVLYFFFLSINMNET

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0003723	RNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.42	0.80
Trophozoite	expressed	0.42	0.75
Schizont	possibly expressed	0.17	0.88
Gametocyte	possibly expressed	0.45	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1333400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.718 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1348100)

Relative Growth Rate: 1.05 ± 0.16
Confidence: 5.05

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1348100)

Modification: Disrupted | RMgm-3632

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101067

Most Similar Human Ortholog: A0A7P0Z454

TM-align score: 0.79 | RMSD: 1.51

Seq Identity: 0.32 | Length: 198 / 260

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000101935	AMMECR nuclear protein 1
ENSG00000144233	AMMECR1 like

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	14	9	12
disruptive	2	16	4	22
missense	2	15	4	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	24	7	13
disruptive	5	34	17	48
missense	4	29	17	36

PlasmoDB Total SNPs: 57

Non-coding: 46 | Synonymous: 7 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 260 | Molecular Weight (kDa): 30.891

UniProt ID(s): None

PDB ID(s): None

Isoelectric Point: 8.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002733	AMMECR1 domain
InterPro	IPR023473	AMMECR1
InterPro	IPR036071	AMMECR1 domain superfamily
PFam	PF01871	AMMECR1 domain
Superfamily	SSF143447	AMMECR1 domain superfamily