Genome location: Pf3D7_13_v3:1,372,985..1,377,791(-)
Genome classification: Core
Product Description: U3 small nucleolar RNA-associated protein 4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030686 | 90S preribosome |
| Component | GO:0016020 | membrane |
| Component | GO:0005730 | nucleolus |
| Component | GO:0032040 | small-subunit processome |
| Component | GO:0034455 | t-UTP complex |
| Process | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 1.15 | 0.50 |
| Trophozoite | expressed | 0.77 | 0.61 |
| Schizont | not expressed | 0.25 | 0.86 |
| Gametocyte | not expressed | 0.66 | 0.64 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1333600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.143 | MFS: -2.859 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDZ2
"Best" AlphaFill ligand hit: NDP (nadph dihydro-nicotinamide-adenine-dinucleotide phosphate, Local RMSD=2.48) with 8JFB (Global RMSD=23.00)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 71 | 36 | 87 |
| disruptive | 97 | 246 | 123 | 280 |
| missense | 41 | 160 | 85 | 190 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 30 | 117 | 53 | 92 |
| disruptive | 164 | 439 | 186 | 354 |
| missense | 75 | 295 | 132 | 212 |
PlasmoDB Total SNPs: 259
Non-coding: 98 | Synonymous: 85 | Nonsynonymous: 76 | Stop Codon: 0
Protein Length: 1335 | Molecular Weight (kDa): 159.338
UniProt ID(s): Q8IDZ2
PDB ID(s): None
Isoelectric Point: 8.17
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 32524281 | Anti-infective nitazoxanide disrupts transcription of ribosome biogenesis-relatedgenes in yeast | Xu S, Yamamoto N | 10.1007/s13258-020-00958-0 |
| 24219289 | Interaction, mobility, and phosphorylation of human orthologues of WDrepeat-containing components of the yeast SSU processome t-UTP sub-complex | Sato M, Araki N, ..., Horigome T | 10.1139/bcb-2013-0062 |