Genome location: Pf3D7_13_v3:1,378,294..1,380,973(-)
Genome classification: Core
Product Description: histone H3-like centromeric protein CSE4
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000775 | chromosome, centromeric region |
| Component | GO:0034399 | nuclear periphery |
| Component | GO:0000786 | nucleosome |
| Component | GO:0005634 | nucleus |
| Function | GO:0003677 | DNA binding |
| Process | GO:0006333 | chromatin assembly or disassembly |
| Process | GO:0007059 | chromosome segregation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.24 | 0.84 |
| Schizont | expressed | 0.47 | 0.70 |
| Gametocyte | expressed | 0.50 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1333700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.408 | MFS: -2.685 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1348400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDZ1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 148
Non-coding: 145 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 170 | Molecular Weight (kDa): 19.628
UniProt ID(s): Q8IDZ1
PDB ID(s): None
Isoelectric Point: 11.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000164 | Histone H3/CENP-A |
| InterPro | IPR007125 | Histone H2A/H2B/H3 |
| InterPro | IPR009072 | Histone-fold |
| PFam | PF00125 | Histone H2A/H2B/H3 |
| Superfamily | SSF47113 | Histone-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 22507744 | Plasmodium falciparum centromeres display a unique epigenetic makeup and clusterprior to and during schizogony. | Hoeijmakers WA, Flueck C, ..., Bartfai R | 10.1111/j.1462-5822.2012.01803.x |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24316361 | Plasmodium falciparum CENH3 is able to functionally complement Cse4p and its,C-terminus is essential for centromere function. | Verma G, Surolia N | 10.1016/j.molbiopara.2013.11.002 |