PF3D7_1333800

Genome location: Pf3D7_13_v3:1,380,836..1,383,978(+)

Genome classification: Core

Function and Localization

Product Description: Voldacs domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.23	0.89
Trophozoite	expressed	0.38	0.77
Schizont	expressed	0.13	0.91
Gametocyte	expressed	0.23	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1333800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.693 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8U1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103509

Most Similar Human Ortholog: E9PQ83

TM-align score: 0.64 | RMSD: 2.60

Seq Identity: 0.36 | Length: 45 / 234

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000074201	chloride nucleotide-sensitive channel 1A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	10	15	15
disruptive	13	29	13	41
missense	9	26	11	37

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	22	17	13
disruptive	18	60	23	74
missense	12	48	14	50

PlasmoDB Total SNPs: 139

Non-coding: 112 | Synonymous: 12 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 234 | Molecular Weight (kDa): 27.403

UniProt ID(s): A0A5K1K8U1

PDB ID(s): None

Isoelectric Point: 3.83

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR039924	ICln/Lot5
PFam	PF03517	ICln/Lot5
Superfamily	N/A	N/A