PF3D7_1333900

Genome location: Pf3D7_13_v3:1,384,922..1,389,288(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	not expressed	0.50	0.70
Schizont	not expressed	0.17	0.89
Gametocyte	not expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1333900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.889 | MFS: -1.742 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9F2

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.15) with 2XZO (Global RMSD=3.09)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112541

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	57	44	58
disruptive	55	141	87	206
missense	30	110	72	172

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	115	47	86
disruptive	103	337	186	314
missense	54	240	148	207

PlasmoDB Total SNPs: 317

Non-coding: 73 | Synonymous: 134 | Nonsynonymous: 110 | Stop Codon: 0

Protein Information

Protein Length: 1328 | Molecular Weight (kDa): 158.616

UniProt ID(s): A0A5K1K9F2

PDB ID(s): None

Isoelectric Point: 9.31

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027351	(+) RNA virus helicase core domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR041679	DNA2/NAM7 helicase-like, C-terminal
PFam	PF01443	(+) RNA virus helicase core domain
PFam	PF13087	DNA2/NAM7 helicase-like, C-terminal
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase