PF3D7_1334000

Genome location: Pf3D7_13_v3:1,389,425..1,391,366(-)

Genome classification: Core

Function and Localization

Product Description: RING zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	expressed	0.24	0.84
Schizont	expressed	0.16	0.89
Gametocyte	expressed	1.01	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1334000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.161 | MFS: -3.391 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDY8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107085

Most Similar Human Ortholog: E7EVC4

TM-align score: 0.54 | RMSD: 2.31

Seq Identity: 0.26 | Length: 66 / 445

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000183763	TRAF interacting protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	17	13	31
disruptive	6	25	11	58
missense	6	24	11	52

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	50	17	25
disruptive	12	65	37	89
missense	9	59	33	67

PlasmoDB Total SNPs: 47

Non-coding: 27 | Synonymous: 13 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 445 | Molecular Weight (kDa): 52.543

UniProt ID(s): Q8IDY8

PDB ID(s): None

Isoelectric Point: 9.46

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001841	Zinc finger, RING-type
PFam	PF13639	Zinc finger, RING-type
Superfamily	SSF57850	N/A