About Gene List

PF3D7_1334100 (ORC4)

Genome location: Pf3D7_13_v3:1,392,263..1,396,454(-)

Genome classification: Core

Function and Localization

Product Description: origin recognition complex subunit 4, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.11 0.95
Trophozoite expressed 0.83 0.56
Schizont expressed 0.28 0.84
Gametocyte expressed 0.76 0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1334100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.175 | MFS: -2.71 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8V1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103029

Most Similar Human Ortholog: C9J2X8

TM-align score: 0.72 | RMSD: 3.47

Seq Identity: 0.17 | Length: 126 / 983

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000115947 origin recognition complex subunit 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 42 22 70
disruptive 22 101 63 147
missense 13 79 55 112

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 17 95 36 71
disruptive 47 213 110 240
missense 26 154 85 159

PlasmoDB Total SNPs: 199

Non-coding: 132 | Synonymous: 42 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 983 | Molecular Weight (kDa): 117.79

UniProt ID(s): A0A5K1K8V1

PDB ID(s): None

Isoelectric Point: 7.47

Protein Domain Annotations:

Source Family ID Description
InterPro IPR016527 Origin recognition complex subunit 4
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFam N/A N/A
Superfamily SSF52540 P-loop containing nucleoside triphosphate hydrolase

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
33397927 Humanizing the yeast origin recognition complex Lee CSK, Cheung MF, ..., Tye BK 10.1038/s41467-020-20277-y