About Gene List

PF3D7_1334200

Genome location: Pf3D7_13_v3:1,397,512..1,399,983(+)

Genome classification: Core

Function and Localization

Product Description: chaperone binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.63 0.71
Trophozoite expressed 1.03 0.51
Schizont not expressed 0.09 0.94
Gametocyte not expressed 0.57 0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1334200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.7 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K963

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119584

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 21 12 29
disruptive 3 34 20 75
missense 2 29 19 62

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 41 25 33
disruptive 14 102 72 146
missense 7 73 58 87

PlasmoDB Total SNPs: 105

Non-coding: 62 | Synonymous: 29 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 524 | Molecular Weight (kDa): 62.674

UniProt ID(s): A0A5K1K963

PDB ID(s): None

Isoelectric Point: 8.45

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
InterPro IPR015310 Activator of Hsp90 ATPase, N-terminal
InterPro IPR036338 Activator of Hsp90 ATPase, Aha1
InterPro IPR039663 AIP/AIPL1
PFam PF09229 Activator of Hsp90 ATPase, N-terminal
Superfamily SSF103111 Activator of Hsp90 ATPase, Aha1
Superfamily SSF48452 Tetratricopeptide-like helical domain superfamily

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108