Genome location: Pf3D7_13_v3:1,400,682..1,402,748(-)
Genome classification: Core
Product Description: MSP7-like protein
SignalP Peptide: MQSEFFICVTFFFVLLHYISC
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0043657 | host cell |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.17 | 0.92 |
| Trophozoite | possibly expressed | 0.88 | 0.57 |
| Schizont | not expressed | 0.13 | 0.93 |
| Gametocyte | not expressed | 0.26 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1334300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.451 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDY5
"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=5.81) with 2I0Z (Global RMSD=21.03)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 17 | 9 | 25 |
| disruptive | 29 | 65 | 47 | 88 |
| missense | 14 | 41 | 32 | 52 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 39 | 16 | 20 |
| disruptive | 48 | 127 | 73 | 137 |
| missense | 22 | 83 | 49 | 73 |
PlasmoDB Total SNPs: 115
Non-coding: 27 | Synonymous: 40 | Nonsynonymous: 48 | Stop Codon: 0
Protein Length: 459 | Molecular Weight (kDa): 54.352
UniProt ID(s): C5HE60, C5HE68, C5HE87, C5HE88, C5HE89, C5HE91, C5HE92, C5HE93, C5HE94, C5HE95, C5HE96, C5HE97, C5HE98, C5HEA1, C5HEA2, C5HEA3, Q8IDY5
PDB ID(s): None
Isoelectric Point: 3.99
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR024781 | Merozoite surface protein, C-terminal |
| PFam | PF12948 | Merozoite surface protein, C-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23950716 | Identification of new PNEPs indicates a substantial non-PEXEL exportome andunderpins common features in Plasmodium falciparum protein export. | Heiber A, Kruse F, ..., Spielmann T | 10.1371/journal.ppat.1003546 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 20472690 | Systematic genetic analysis of the Plasmodium falciparum MSP7-like family revealsdifferences in protein expression, location, and importance in asexual growth ofthe blood-stage parasite | Kadekoppala M, Ogun SA, ..., Holder AA | 10.1128/EC.00048-10 |
| 18820076 | Deletion of the Plasmodium falciparum merozoite surface protein 7 gene impairsparasite invasion of erythrocytes | Kadekoppala M, O'Donnell RA, ..., Holder AA | 10.1128/EC.00274-08 |