PF3D7_1334400 (MSRP4)

Genome location: Pf3D7_13_v3:1,403,522..1,404,451(-)

Genome classification: Core

Function and Localization

Product Description: MSP7-like protein

SignalP Peptide: MKGRIISFSFFLFCMVHFVFC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.02	0.98
Gametocyte	not expressed	0.03	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1334400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.036 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDY4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149563

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	10	11
disruptive	15	27	26	61
missense	13	26	25	51

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	20	15	19
disruptive	20	75	35	78
missense	17	64	31	55

PlasmoDB Total SNPs: 21

Non-coding: 0 | Synonymous: 4 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 309 | Molecular Weight (kDa): 36.383

UniProt ID(s): C5HE69, C5HE70, C5HE71, C5HE72, C5HE73, C5HE74, C5HE75, C5HE80, C5HE81, C5HE85, Q8IDY4

PDB ID(s): None

Isoelectric Point: 9.03

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR024781	Merozoite surface protein, C-terminal
PFam	PF12948	Merozoite surface protein, C-terminal
Superfamily	N/A	N/A