PF3D7_1334500 (MSRP6)

Genome location: Pf3D7_13_v3:1,405,046..1,408,182(-)

Genome classification: Core

Function and Localization

Product Description: MSP7-like protein

SignalP Peptide: MKSKKIICSSCLFLIFLSVIFC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020036	Maurer's cleft

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.13	0.94
Trophozoite	expressed	0.87	0.57
Schizont	expressed	0.05	0.97
Gametocyte	not expressed	0.09	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1334500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.232 | MFS: -2.637 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDY3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533463

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	15	11	17
disruptive	84	101	54	135
missense	43	60	38	104

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	29	16	27
disruptive	108	199	92	144
missense	55	124	64	84

PlasmoDB Total SNPs: 224

Non-coding: 117 | Synonymous: 42 | Nonsynonymous: 65 | Stop Codon: 0

Protein Information

Protein Length: 593 | Molecular Weight (kDa): 70.661

UniProt ID(s): C5HEL6, C5HEL7, C5HEL8, C5HEL9, C5HEM1, C5HEM2, C5HEM3, C5HEM5, C5HEM7, C5HEM8, C5HEM9, Q8IDY3

PDB ID(s): None

Isoelectric Point: 4.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR024781	Merozoite surface protein, C-terminal
PFam	PF12948	Merozoite surface protein, C-terminal
Superfamily	N/A	N/A