PF3D7_1334600 (MSRP3)

Genome location: Pf3D7_13_v3:1,408,270..1,410,124(-)

Genome classification: Core

Function and Localization

Product Description: MSP7-like protein

SignalP Peptide: MIKGLIFYLFICFFVFFVHA

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	possibly expressed	0.19	0.88
Schizont	expressed	0.30	0.81
Gametocyte	not expressed	0.09	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1334600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.12 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5F3

"Best" AlphaFill ligand hit: M77 (5-(1,4-diazepan-1-sulfonyl)isoquinoline, Local RMSD=1.60) with 2ESM (Global RMSD=15.48)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149563

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	8	4	11
disruptive	9	40	31	39
missense	8	39	29	35

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	13	8	18
disruptive	20	78	39	66
missense	16	71	36	50

PlasmoDB Total SNPs: 55

Non-coding: 28 | Synonymous: 10 | Nonsynonymous: 15 | Stop Codon: 2

Protein Information

Protein Length: 298 | Molecular Weight (kDa): 34.958

UniProt ID(s): C0H5F3, C5HER3, C5HER5, C5HER6, C5HER7, C5HES2, C5HES3, C5HES4, C5HES6, C5HES7, C5HET0

PDB ID(s): None

Isoelectric Point: 5.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR024781	Merozoite surface protein, C-terminal
PFam	PF12948	Merozoite surface protein, C-terminal
Superfamily	N/A	N/A