PF3D7_1334700 (MSRP7)

Genome location: Pf3D7_13_v3:1,410,493..1,412,171(-)

Genome classification: Core

Function and Localization

Product Description: MSP7-like protein

SignalP Peptide: MKRTRHITVFIFSAFLFLLNYATT

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020020	food vacuole
Component	GO:0044164	host cell cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	1.22	0.50
Trophozoite	expressed	0.36	0.79
Schizont	expressed	0.16	0.91
Gametocyte	possibly expressed	0.15	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1334700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.167 | MFS: -3.236 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K987

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532467

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	10	3	18
disruptive	4	10	10	39
missense	4	10	10	34

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	17	8	16
disruptive	6	40	23	49
missense	5	33	22	37

PlasmoDB Total SNPs: 65

Non-coding: 51 | Synonymous: 9 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 202 | Molecular Weight (kDa): 22.986

UniProt ID(s): A0A5K1K987, C5HEN1, C5HEN2, C5HEP0

PDB ID(s): None

Isoelectric Point: 5.29

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR024781	Merozoite surface protein, C-terminal
PFam	PF12948	Merozoite surface protein, C-terminal
Superfamily	N/A	N/A