Genome location: Pf3D7_13_v3:1,412,213..1,413,947(-)
Genome classification: Core
Product Description: MSP7-like protein
SignalP Peptide: MKGQAIYFVFVFLYFLNCVGC
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0020003 | symbiont-containing vacuole |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.54 | 0.71 |
| Schizont | expressed | 0.35 | 0.81 |
| Gametocyte | possibly expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1334800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.993 | MFS: -2.648 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDY0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 71
Non-coding: 61 | Synonymous: 5 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 281 | Molecular Weight (kDa): 32.811
UniProt ID(s): C5HE50, C5HE51, C5HE53, C5HE54, C5HE55, C5HE57, C5HE59, C5HE61, C5HE62, C5HE63, C5HE65, C5HE66, Q8IDY0
PDB ID(s): None
Isoelectric Point: 6.3
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR024781 | Merozoite surface protein, C-terminal |
| PFam | PF12948 | Merozoite surface protein, C-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12477792 | A multigene family that interacts with the amino terminus of plasmodium MSP-1identified using the yeast two-hybrid system. | Mello K, Daly TM, ..., Bergman LW | 10.1128/EC.1.6.915-925.2002 |
| 20472690 | Systematic genetic analysis of the Plasmodium falciparum MSP7-like family revealsdifferences in protein expression, location, and importance in asexual growth ofthe blood-stage parasite. | Kadekoppala M, Ogun SA, ..., Holder AA | 10.1128/EC.00048-10 |
| 21220481 | Global identification of multiple substrates for Plasmodium falciparum SUB1, anessential malarial processing protease | Silmon de Monerri NC, Flynn HR, ..., Blackman MJ | 10.1128/IAI.00902-10 |
| 14742548 | Members of the merozoite surface protein 7 family with similar expressionpatterns differ in ability to protect against Plasmodium yoelii malaria | Mello K, Daly TM, ..., Bergman LW | 10.1128/IAI.72.2.1010-1018.2004 |