About Gene List

PF3D7_1335000 (MSRP1)

Genome location: Pf3D7_13_v3:1,415,833..1,417,543(-)

Genome classification: Core

Function and Localization

Product Description: MSP7-like protein

SignalP Peptide: MKRQIILFTSLFIFSLNLTLS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.01 1.00
Trophozoite possibly expressed 0.01 1.00
Schizont expressed 0.10 0.95
Gametocyte not expressed 0.01 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1335000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.197 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1349100)

Modification: Disrupted | RMgm-3637

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDX9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533264

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 10 9 17
disruptive 7 51 23 71
missense 7 48 22 69

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 19 13 21
disruptive 15 106 30 90
missense 15 98 27 78

PlasmoDB Total SNPs: 44

Non-coding: 27 | Synonymous: 5 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 380 | Molecular Weight (kDa): 42.877

UniProt ID(s): C5HE32, C5HE43, C5HE48, Q8IDX9

PDB ID(s): None

Isoelectric Point: 4.94

Protein Domain Annotations:

Source Family ID Description
InterPro IPR024781 Merozoite surface protein, C-terminal
PFam PF12948 Merozoite surface protein, C-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12477792 A multigene family that interacts with the amino terminus of plasmodium MSP-1identified using the yeast two-hybrid system. Mello K, Daly TM, ..., Bergman LW 10.1128/EC.1.6.915-925.2002
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
20472690 Systematic genetic analysis of the Plasmodium falciparum MSP7-like family revealsdifferences in protein expression, location, and importance in asexual growth ofthe blood-stage parasite Kadekoppala M, Ogun SA, ..., Holder AA 10.1128/EC.00048-10
25080477 New antigens for a multicomponent blood-stage malaria vaccine Osier FH, Mackinnon MJ, ..., Marsh K 10.1126/scitranslmed.3008705
31086187 Plasmodium falciparum sexual differentiation in malaria patients is associatedwith host factors and GDV1-dependent genes Usui M, Prajapati SK, ..., Williamson KC 10.1038/s41467-019-10172-6