Genome location: Pf3D7_13_v3:1,415,833..1,417,543(-)
Genome classification: Core
Product Description: MSP7-like protein
SignalP Peptide: MKRQIILFTSLFIFSLNLTLS
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0009986 | cell surface |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.01 | 1.00 |
Trophozoite | possibly expressed | 0.01 | 1.00 |
Schizont | expressed | 0.10 | 0.95 |
Gametocyte | not expressed | 0.01 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1335000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.197 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1349100)
Modification: Disrupted | RMgm-3637
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDX9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 3 | 10 | 9 | 17 |
disruptive | 7 | 51 | 23 | 71 |
missense | 7 | 48 | 22 | 69 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 4 | 19 | 13 | 21 |
disruptive | 15 | 106 | 30 | 90 |
missense | 15 | 98 | 27 | 78 |
PlasmoDB Total SNPs: 44
Non-coding: 27 | Synonymous: 5 | Nonsynonymous: 12 | Stop Codon: 0
Protein Length: 380 | Molecular Weight (kDa): 42.877
UniProt ID(s): C5HE32, C5HE43, C5HE48, Q8IDX9
PDB ID(s): None
Isoelectric Point: 4.94
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR024781 | Merozoite surface protein, C-terminal |
PFam | PF12948 | Merozoite surface protein, C-terminal |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12477792 | A multigene family that interacts with the amino terminus of plasmodium MSP-1identified using the yeast two-hybrid system. | Mello K, Daly TM, ..., Bergman LW | 10.1128/EC.1.6.915-925.2002 |
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
20472690 | Systematic genetic analysis of the Plasmodium falciparum MSP7-like family revealsdifferences in protein expression, location, and importance in asexual growth ofthe blood-stage parasite | Kadekoppala M, Ogun SA, ..., Holder AA | 10.1128/EC.00048-10 |
25080477 | New antigens for a multicomponent blood-stage malaria vaccine | Osier FH, Mackinnon MJ, ..., Marsh K | 10.1126/scitranslmed.3008705 |
31086187 | Plasmodium falciparum sexual differentiation in malaria patients is associatedwith host factors and GDV1-dependent genes | Usui M, Prajapati SK, ..., Williamson KC | 10.1038/s41467-019-10172-6 |