Genome location: Pf3D7_13_v3:1,418,213..1,421,552(-)
Genome classification: Core
Product Description: merozoite surface protein 7
SignalP Peptide: MKSNIIFYFSFFFVYLYYVSC
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
| Function | GO:0046789 | host cell surface receptor binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.19 | 0.91 |
| Trophozoite | not expressed | 0.30 | 0.84 |
| Schizont | expressed | 2.83 | 0.11 |
| Gametocyte | not expressed | 0.06 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1335100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.459 | MFS: -2.577 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1349100)
Modification: Disrupted | RMgm-1319
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDX8
"Best" AlphaFill ligand hit: GSH (glutathione, Local RMSD=0.59) with 6FXE (Global RMSD=16.36)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 2 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 3 | 1 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 150
Non-coding: 111 | Synonymous: 10 | Nonsynonymous: 29 | Stop Codon: 0
Protein Length: 351 | Molecular Weight (kDa): 41.276
UniProt ID(s): C5HEE1, C5HEE2, C5HWI4, C5HWI8, C5HWK4, C5HWK6, C5HWN3, C5HWQ7, Q000Q0, Q000Q4, Q8IDX8, Q95NH8, Q95VZ1
PDB ID(s): None
Isoelectric Point: 4.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR024781 | Merozoite surface protein, C-terminal |
| PFam | PF12948 | Merozoite surface protein, C-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11551634 | The 22 kDa component of the protein complex on the surface of Plasmodiumfalciparum merozoites is derived from a larger precursor, merozoite surfaceprotein 7. | Pachebat JA, Ling IT, ..., Holder AA | 10.1016/s0166-6851(01)00336-x |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 16940297 | Interactions between merozoite surface proteins 1, 6, and 7 of the malariaparasite Plasmodium falciparum. | Kauth CW, Woehlbier U, ..., Bujard H | 10.1074/jbc.M604641200 |
| 17944453 | Identifying merozoite surface protein 4 and merozoite surface protein 7Plasmodium falciparum protein family members specifically binding to humanerythrocytes suggests a new malarial parasite-redundant survival mechanism. | Garcia Y, Puentes A, ..., Patarroyo ME | 10.1021/jm070773z |
| 20472690 | Systematic genetic analysis of the Plasmodium falciparum MSP7-like family revealsdifferences in protein expression, location, and importance in asexual growth ofthe blood-stage parasite. | Kadekoppala M, Ogun SA, ..., Holder AA | 10.1128/EC.00048-10 |
| 23049905 | Genetic diversity and selection in three Plasmodium vivax merozoite surfaceprotein 7 (Pvmsp-7) genes in a Colombian population. | Garzon-Ospina D, Lopez C, Forero-Rodriguez J, Patarroyo MA | 10.1371/journal.pone.0045962 |
| 26045295 | P-selectin is a host receptor for Plasmodium MSP7 ligands. | Perrin AJ, Bartholdson SJ, Wright GJ | 10.1186/s12936-015-0750-z |
| 26823464 | Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes MediateMerozoite Binding to Human Erythrocytes. | Lin CS, Uboldi AD, ..., Cowman AF | 10.1074/jbc.M115.698282 |
| 28163236 | Evolution of the merozoite surface protein 7 (msp7) family in Plasmodium vivaxand P. falciparum: A comparative approach. | Castillo AI, Andreina Pacheco M, Escalante AA | 10.1016/j.meegid.2017.01.024 |
| 29138437 | Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the innermembrane complex and is required for Plasmodium parasite development. | Saini E, Zeeshan M, ..., Tewari R | 10.1038/s41598-017-15781-z |
| 29760216 | Plasmodium falciparum M SP3 Exists in a Complex on the Merozoite Surface and Generates Antibody Response during Natural Infection | Deshmukh A, Chourasia BK, ..., Malhotra P | 10.1128/IAI.00067-18 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 26701602 | A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New VaccineCandidates and Protein-Protein Interactions | Hostetler JB, Sharma S, ..., Rayner JC | 10.1371/journal.pntd.0004264 |
| 31035999 | Plasmodium knowlesi clinical isolates from Malaysia show extensive diversity andstrong differential selection pressure at the merozoite surface protein 7D(MSP7D) | Ahmed MA, Quan FS | 10.1186/s12936-019-2782-2 |
| 29718980 | Polymorphism in merozoite surface protein-7E of Plasmodium vivax in Thailand:Natural selection related to protein secondary structure | Cheng CW, Putaporntip C, Jongwutiwes S | 10.1371/journal.pone.0196765 |
| 36396703 | The first complete genome of the simian malaria parasite Plasmodium brasilianum | Bajic M, Ravishankar S, ..., Talundzic E | 10.1038/s41598-022-20706-6 |
| 27618921 | Effect of recombinant malarial antigen on monocyte functionality | Saha A, Chauhan S, Bagchi T | 10.1093/trstmh/trw049 |
| 37662206 | Analytic optimization of Plasmodium falciparum marker gene haplotype recoveryfrom amplicon deep sequencing of complex mixtures | Lapp Z, Freedman E, ..., Taylor SM | 10.1101/2023.08.17.23294237 |
| 35836171 | Heterogeneity in prevalence of subclinical Plasmodium falciparum and Plasmodiumvivax infections but no parasite genomic clustering in the Chittagong HillTracts, Bangladesh | Huwe T, Kibria MG, ..., Koepfli C | 10.1186/s12936-022-04236-0 |
| 32849480 | New Plasmodium vivax Genomes From the China-Myanmar Border | Brashear AM, Huckaby AC, ..., Cui L | 10.3389/fmicb.2020.01930 |
| 38087335 | Amplicon deep sequencing of five highly polymorphic markers of Plasmodiumfalciparum reveals high parasite genetic diversity and moderate populationstructure in Ethiopia | Reda AG, Huwe T, ..., Mamo H | 10.1186/s12936-023-04814-w |
| 35141172 | Antigen Discovery in Circulating Extracellular Vesicles From Plasmodium vivaxPatients | Aparici-Herraiz I, Gualdron-Lopez M, ..., Del Portillo HA | 10.3389/fcimb.2021.811390 |
| 26222913 | Global expression profiling reveals shared and distinct transcript signatures inarrested act2(-) and CDPK4(-) Plasmodium berghei gametocytes | Andreadaki M, Mollenkopf HJ, ..., Siden-Kiamos I | 10.1016/j.molbiopara.2015.07.001 |
| 31196098 | Clinical expression and antigenic profiles of a Plasmodium vivax vaccinecandidate: merozoite surface protein 7 (PvMSP-7) | Cheng CW, Jongwutiwes S, Putaporntip C, Jackson AP | 10.1186/s12936-019-2826-7 |
| 35637187 | Stochastic expression of invasion genes in Plasmodium falciparum schizonts | Tripathi J, Zhu L, ..., Bozdech Z | 10.1038/s41467-022-30605-z |
| 28662682 | Pooled-DNA sequencing identifies genomic regions of selection in Nigerianisolates of Plasmodium falciparum | Oyebola KM, Idowu ET, ..., Amambua-Ngwa A | 10.1186/s13071-017-2260-z |
| 29217416 | Identification of target proteins of clinical immunity to Plasmodium falciparumin a region of low malaria transmission | Sakamoto H, Takeo S, ..., Tsuboi T | 10.1016/j.parint.2017.12.002 |