PF3D7_1335600

Genome location: Pf3D7_13_v3:1,454,260..1,456,075(+)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.29	0.86
Trophozoite	possibly expressed	0.34	0.79
Schizont	possibly expressed	0.22	0.86
Gametocyte	not expressed	0.26	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1335600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.178 | MFS: -2.869 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1349500)

Relative Growth Rate: 0.11 ± 0.07
Confidence: 6.62

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDX4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179352

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	10	5	15
disruptive	6	21	10	42
missense	3	18	7	34

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	19	14	23
disruptive	10	53	36	87
missense	4	30	28	55

PlasmoDB Total SNPs: 69

Non-coding: 43 | Synonymous: 19 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 411 | Molecular Weight (kDa): 48.871

UniProt ID(s): Q8IDX4

PDB ID(s): None

Isoelectric Point: 9.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily