PF3D7_1335700 (COG3)

Genome location: Pf3D7_13_v3:1,456,097..1,461,662(-)

Genome classification: Core

Function and Localization

Product Description: conserved oligomeric Golgi complex subunit 3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0006891	intra-Golgi vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.93
Trophozoite	not expressed	1.07	0.47
Schizont	expressed	0.72	0.61
Gametocyte	not expressed	0.61	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1335700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.041 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDX3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532636

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	39	20	48
disruptive	48	141	75	188
missense	37	119	70	161

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	59	39	74
disruptive	89	270	141	330
missense	64	216	113	241

PlasmoDB Total SNPs: 114

Non-coding: 37 | Synonymous: 44 | Nonsynonymous: 33 | Stop Codon: 0

Protein Information

Protein Length: 1609 | Molecular Weight (kDa): 193.638

UniProt ID(s): Q8IDX3

PDB ID(s): None

Isoelectric Point: 5.07

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A