PF3D7_1335800

Genome location: Pf3D7_13_v3:1,462,045..1,464,260(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.11	0.95
Trophozoite	possibly expressed	0.87	0.54
Schizont	possibly expressed	0.53	0.69
Gametocyte	not expressed	0.60	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1335800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.926 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1349700)

Relative Growth Rate: 0.95 ± 0.17
Confidence: 4.93

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1349700)

Modification: Disrupted | RMgm-3641

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDX2

"Best" AlphaFill ligand hit: ACP (adenosine-5'-[beta, gamma-methylene]triphosphate, Local RMSD=0.09) with 2HCB (Global RMSD=21.15)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533380

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	8	6	18
disruptive	10	34	22	58
missense	9	34	19	55

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	15	10	25
disruptive	23	89	54	124
missense	15	69	46	94

PlasmoDB Total SNPs: 64

Non-coding: 25 | Synonymous: 19 | Nonsynonymous: 19 | Stop Codon: 1

Protein Information

Protein Length: 603 | Molecular Weight (kDa): 73.596

UniProt ID(s): Q8IDX2

PDB ID(s): None

Isoelectric Point: 8.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A