PF3D7_1336000

Genome location: Pf3D7_13_v3:1,469,753..1,471,997(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.64	0.69
Trophozoite	not expressed	0.44	0.73
Schizont	possibly expressed	0.24	0.84
Gametocyte	not expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1336000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.305 | MFS: -3.419 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1349900)

Relative Growth Rate: 0.06 ± 0.13
Confidence: 5.48

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDX1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532922

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	18	4	17
disruptive	3	12	9	45
missense	3	12	9	40

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	29	9	25
disruptive	8	29	32	79
missense	5	22	27	61

PlasmoDB Total SNPs: 115

Non-coding: 94 | Synonymous: 11 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 399 | Molecular Weight (kDa): 47.017

UniProt ID(s): Q8IDX1

PDB ID(s): None

Isoelectric Point: 8.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A