PF3D7_1336100

Genome location: Pf3D7_13_v3:1,472,056..1,473,319(+)

Genome classification: Core

Function and Localization

Product Description: WPP motif-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.24	0.84
Schizont	not expressed	0.08	0.94
Gametocyte	not expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1336100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.281 | MFS: -2.848 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1350000)

Modification: Tagged | RMgm-4971

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5F6

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.34) with 4BEC (Global RMSD=20.11)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160750

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	rare	doubleton	singleton
synonymous	5	2	6
disruptive	11	2	11
missense	11	2	10

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	8	7	6
disruptive	4	16	12	30
missense	4	11	11	15

PlasmoDB Total SNPs: 98

Non-coding: 96 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 155 | Molecular Weight (kDa): 18.63

UniProt ID(s): C0H5F6

PDB ID(s): None

Isoelectric Point: 10.54

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A