PF3D7_1336200

Genome location: Pf3D7_13_v3:1,473,321..1,476,255(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.12	0.94
Trophozoite	expressed	0.80	0.57
Schizont	expressed	0.20	0.87
Gametocyte	expressed	0.63	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1336200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.816 | MFS: -2.335 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDW9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215371

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	6	7	17
disruptive	6	43	15	63
missense	6	42	13	59

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	18	13	21
disruptive	14	112	48	90
missense	10	95	41	63

PlasmoDB Total SNPs: 127

Non-coding: 113 | Synonymous: 10 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 297 | Molecular Weight (kDa): 35.497

UniProt ID(s): Q8IDW9

PDB ID(s): None

Isoelectric Point: 10.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A