PF3D7_1336300

Genome location: Pf3D7_13_v3:1,476,333..1,477,407(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.02	0.99
Trophozoite	no data	0.05	0.97
Schizont	no data	0.02	0.99
Gametocyte	no data	0.23	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1336300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.427 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDW8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532530

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	8	18
disruptive	3	16	10	38
missense	3	16	10	34

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	24	14	17
disruptive	6	52	35	68
missense	4	38	25	51

PlasmoDB Total SNPs: 21

Non-coding: 10 | Synonymous: 8 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 324 | Molecular Weight (kDa): 40.052

UniProt ID(s): Q8IDW8

PDB ID(s): None

Isoelectric Point: 10.19

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A