PF3D7_1336400

Genome location: Pf3D7_13_v3:1,477,391..1,482,233(-)

Genome classification: Core

Function and Localization

Product Description: RanBPM and CLTH-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005634	nucleus
Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.12	0.93
Trophozoite	not expressed	0.23	0.85
Schizont	possibly expressed	0.07	0.95
Gametocyte	possibly expressed	0.63	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1336400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.258 | MFS: -3.348 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDW7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102654

Most Similar Human Ortholog: Q9NWU2

TM-align score: 0.64 | RMSD: 4.48

Seq Identity: 0.22 | Length: 216 / 282

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000101193	GID complex subunit 8 homolog

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	0
disruptive	0	0	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 288

Non-coding: 277 | Synonymous: 9 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 282 | Molecular Weight (kDa): 33.734

UniProt ID(s): Q8IDW7

PDB ID(s): None

Isoelectric Point: 8.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006595	CTLH, C-terminal LisH motif
InterPro	IPR013144	CRA domain
InterPro	IPR024964	CTLH/CRA C-terminal to LisH motif domain
PFam	PF10607	CTLH/CRA C-terminal to LisH motif domain
Superfamily	N/A	N/A