Genome location: Pf3D7_13_v3:1,482,259..1,484,407(-)
Genome classification: Core
Product Description: parasitophorous vacuolar protein 3, putative
SignalP Peptide: MVPKNILFIFVILFHLIGYLKN
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020003 | symbiont-containing vacuole |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.37 | 0.40 |
| Trophozoite | expressed | 0.89 | 0.53 |
| Schizont | expressed | 0.20 | 0.87 |
| Gametocyte | expressed | 0.62 | 0.67 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1336700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.983 | MFS: -2.1 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1350500)
Modification: Disrupted | RMgm-4538
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDW5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 86
Non-coding: 47 | Synonymous: 20 | Nonsynonymous: 19 | Stop Codon: 0
Protein Length: 158 | Molecular Weight (kDa): 18.268
UniProt ID(s): Q8IDW5
PDB ID(s): None
Isoelectric Point: 3.69
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30232409 | An in silico down-scaling approach uncovers novel constituents of thePlasmodium-containing vacuole. | Matz JM, Matuschewski K | 10.1038/s41598-018-32471-6 |