PF3D7_1336800 (NUDC)

Genome location: Pf3D7_13_v3:1,485,785..1,487,899(+)

Genome classification: Core

Function and Localization

Product Description: nuclear movement protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Function	GO:0051082	unfolded protein binding
Process	GO:0032502	developmental process
Process	GO:0006457	protein folding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.53	0.75
Trophozoite	expressed	1.01	0.50
Schizont	expressed	0.09	0.95
Gametocyte	expressed	0.78	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1336800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.459 | MFS: -2.466 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1350600)

Relative Growth Rate: 0.05 ± 0.06
Confidence: 6.98

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDW4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102007

Most Similar Human Ortholog: Q9Y266

TM-align score: 0.46 | RMSD: 5.48

Seq Identity: 0.32 | Length: 221 / 386

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000090273	nuclear distribution C, dynein complex regulator

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	17	5	17
disruptive	3	18	15	36
missense	3	16	14	30

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	33	11	20
disruptive	10	67	30	99
missense	3	50	21	50

PlasmoDB Total SNPs: 52

Non-coding: 39 | Synonymous: 8 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 386 | Molecular Weight (kDa): 46.017

UniProt ID(s): Q8IDW4

PDB ID(s): None

Isoelectric Point: 5.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007052	CS domain
InterPro	IPR008978	HSP20-like chaperone
InterPro	IPR025934	NudC N-terminal domain
InterPro	IPR037898	NudC family
PFam	PF04969	CS domain
PFam	PF14050	NudC N-terminal domain
Superfamily	SSF49764	HSP20-like chaperone