Genome location: Pf3D7_13_v3:1,491,206..1,494,872(-)
Genome classification: Core
Product Description: mitochondrial intermediate peptidase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.4.24.59 (Mitochondrial intermediate peptidase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.06 | 0.97 |
| Trophozoite | possibly expressed | 0.22 | 0.87 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | possibly expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1337000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.166 | MFS: -2.778 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1350800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K885
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.24.59 | mitochondrial intermediate peptidase | NEMDTTEDTAJA-2bestatinleupeptinpepstatincaptoprilamastatinthiorphaniodoacetamideiodoacetic acid... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102110
Most Similar Human Ortholog: Q99797
TM-align score: 0.83 | RMSD: 3.26
Seq Identity: 0.18 | Length: 649 / 965
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000027001 | mitochondrial intermediate peptidase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 46 | 26 | 61 |
| disruptive | 18 | 110 | 53 | 161 |
| missense | 10 | 96 | 50 | 146 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 85 | 31 | 70 |
| disruptive | 48 | 207 | 99 | 208 |
| missense | 28 | 178 | 89 | 158 |
PlasmoDB Total SNPs: 101
Non-coding: 48 | Synonymous: 27 | Nonsynonymous: 26 | Stop Codon: 0
Protein Length: 965 | Molecular Weight (kDa): 115.535
UniProt ID(s): A0A5K1K885
PDB ID(s): None
Isoelectric Point: 8.6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001567 | Peptidase M3A/M3B catalytic domain |
| InterPro | IPR033851 | Mitochondrial intermediate peptidase |
| PFam | PF01432 | Peptidase M3A/M3B catalytic domain |
| Superfamily | SSF55486 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |