PF3D7_1337400

Genome location: Pf3D7_13_v3:1,506,707..1,509,508(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.59	0.39
Trophozoite	expressed	1.48	0.32
Schizont	expressed	0.67	0.64
Gametocyte	possibly expressed	1.06	0.48

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1337400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.715 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1351200)

Relative Growth Rate: 0.96 ± 0.15
Confidence: 5.20

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1351200)

Modification: Disrupted | RMgm-3650

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8V2

"Best" AlphaFill ligand hit: LLL (gentamicin c1a, Local RMSD=7.83) with 3HAM (Global RMSD=22.02)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103387

Most Similar Human Ortholog: H0YK63

TM-align score: 0.54 | RMSD: 3.38

Seq Identity: 0.02 | Length: 41 / 584

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000103671	thyroid hormone receptor interactor 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	24	18	35
disruptive	16	79	56	138
missense	13	73	53	118

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	52	24	42
disruptive	37	193	98	171
missense	26	160	87	130

PlasmoDB Total SNPs: 125

Non-coding: 74 | Synonymous: 29 | Nonsynonymous: 22 | Stop Codon: 0

Protein Information

Protein Length: 584 | Molecular Weight (kDa): 69.629

UniProt ID(s): A0A5K1K8V2

PDB ID(s): None

Isoelectric Point: 8.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009349	Zinc finger, C2HC5-type
InterPro	IPR039128	Activating signal cointegrator 1-like
PFam	PF06221	Zinc finger, C2HC5-type
Superfamily	N/A	N/A