PF3D7_1337500

Genome location: Pf3D7_13_v3:1,509,051..1,521,971(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.63	0.39
Trophozoite	expressed	1.59	0.30
Schizont	possibly expressed	0.96	0.52
Gametocyte	expressed	2.11	0.16

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1337500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.182 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_125117

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	27	154	67	142
disruptive	130	486	237	571
missense	66	349	171	434

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	66	254	104	168
disruptive	252	893	414	735
missense	127	649	296	464

PlasmoDB Total SNPs: 840

Non-coding: 156 | Synonymous: 351 | Nonsynonymous: 333 | Stop Codon: 0

Protein Information

Protein Length: 3334 | Molecular Weight (kDa): 393.256

UniProt ID(s): A0A5K1K8Y0

PDB ID(s): None

Isoelectric Point: 5.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF57997	N/A