Genome location: Pf3D7_13_v3:1,525,110..1,528,360(+)
Genome classification: Core
Product Description: phosphoinositide-binding protein PH2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Function | GO:0035091 | phosphatidylinositol binding |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.04 | 0.98 |
| Schizont | not expressed | 0.93 | 0.53 |
| Gametocyte | not expressed | 0.29 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1337700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.128 | MFS: -2.925 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDV6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 25 | 22 | 37 |
| disruptive | 10 | 41 | 38 | 79 |
| missense | 10 | 37 | 34 | 65 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 67 | 23 | 35 |
| disruptive | 22 | 105 | 57 | 141 |
| missense | 14 | 86 | 51 | 101 |
PlasmoDB Total SNPs: 186
Non-coding: 151 | Synonymous: 24 | Nonsynonymous: 11 | Stop Codon: 0
Protein Length: 616 | Molecular Weight (kDa): 74.371
UniProt ID(s): Q8IDV6
PDB ID(s): None
Isoelectric Point: 7.59
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | SSF50729 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 31097469 | A pan-apicomplexan phosphoinositide-binding protein acts in malarial micronemeexocytosis | Ebrahimzadeh Z, Mukherjee A, ..., Richard D | 10.15252/embr.201847102 |