PF3D7_1337900

Genome location: Pf3D7_13_v3:1,533,805..1,535,537(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.19	0.90
Trophozoite	no data	0.19	0.88
Schizont	no data	0.09	0.94
Gametocyte	no data	0.09	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1337900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.178 | MFS: -2.929 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8U7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532526

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	18	5	10
disruptive	11	25	18	43
missense	10	25	16	36

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	23	6	11
disruptive	19	69	31	73
missense	15	57	25	42

PlasmoDB Total SNPs: 140

Non-coding: 120 | Synonymous: 11 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 219 | Molecular Weight (kDa): 25.631

UniProt ID(s): A0A5K1K8U7

PDB ID(s): None

Isoelectric Point: 4.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A