PF3D7_1338000

Genome location: Pf3D7_13_v3:1,535,607..1,540,516(+)

Genome classification: Core

Function and Localization

Product Description: LMBR1 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	not expressed	0.41	0.75
Schizont	possibly expressed	0.22	0.84
Gametocyte	not expressed	0.26	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1338000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.913 | MFS: -2.454 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5F8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105928

Most Similar Human Ortholog: A0A3B3IS10

TM-align score: 0.89 | RMSD: 0.46

Seq Identity: 0.10 | Length: 29 / 530

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000168216	LMBR1 domain containing 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	31	17	39
disruptive	1	19	14	46
missense	1	18	14	42

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	69	12	49
disruptive	3	63	49	96
missense	1	46	41	67

PlasmoDB Total SNPs: 441

Non-coding: 413 | Synonymous: 27 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 530 | Molecular Weight (kDa): 62.018

UniProt ID(s): C0H5F8

PDB ID(s): None

Isoelectric Point: 8.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006876	LMBR1-like membrane protein
PFam	PF04791	LMBR1-like membrane protein
Superfamily	N/A	N/A