PF3D7_1338400

Genome location: Pf3D7_13_v3:1,550,500..1,553,305(-)

Genome classification: Core

Function and Localization

Product Description: SprT-like domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0031593	polyubiquitin modification-dependent protein binding
Process	GO:0006974	cellular response to DNA damage stimulus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.02	0.99
Trophozoite	expressed	0.08	0.95
Schizont	expressed	0.18	0.89
Gametocyte	expressed	0.78	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1338400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.556 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1352100)

Relative Growth Rate: 0.97 ± 0.14
Confidence: 5.36

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1352100)

Modification: Disrupted | RMgm-3655

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDU9

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.37) with 6MDW (Global RMSD=10.52)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104384

Most Similar Human Ortholog: Q9H040

TM-align score: 0.41 | RMSD: 3.28

Seq Identity: 0.47 | Length: 203 / 443

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000010072	SprT-like N-terminal domain

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	20	18	25
disruptive	7	37	21	51
missense	5	33	20	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	42	23	38
disruptive	20	79	42	74
missense	11	65	34	60

PlasmoDB Total SNPs: 210

Non-coding: 180 | Synonymous: 19 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 443 | Molecular Weight (kDa): 52.813

UniProt ID(s): Q8IDU9

PDB ID(s): None

Isoelectric Point: 8.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006640	SprT-like
PFam	PF10263	SprT-like
Superfamily	N/A	N/A