PF3D7_1338500

Genome location: Pf3D7_13_v3:1,554,199..1,556,364(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	not expressed	0.25	0.85
Schizont	not expressed	0.05	0.97
Gametocyte	not expressed	0.29	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1338500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.194 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K989

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533612

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	36	19	51
disruptive	20	83	46	148
missense	13	72	44	131

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	68	40	46
disruptive	44	182	97	187
missense	25	147	88	140

PlasmoDB Total SNPs: 62

Non-coding: 0 | Synonymous: 35 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 721 | Molecular Weight (kDa): 87.365

UniProt ID(s): A0A5K1K989

PDB ID(s): None

Isoelectric Point: 9.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	N/A	N/A
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase