About Gene List

PF3D7_1338600

Genome location: Pf3D7_13_v3:1,556,354..1,561,135(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.20 0.91
Trophozoite expressed 0.92 0.52
Schizont expressed 0.70 0.63
Gametocyte expressed 0.50 0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1338600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.133 | MFS: -2.96 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K898

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532409

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 46 34 58
disruptive 44 140 72 159
missense 22 107 62 126

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 28 91 40 74
disruptive 70 257 106 234
missense 36 189 94 179

PlasmoDB Total SNPs: 255

Non-coding: 144 | Synonymous: 68 | Nonsynonymous: 43 | Stop Codon: 0

Protein Information

Protein Length: 947 | Molecular Weight (kDa): 112.182

UniProt ID(s): A0A5K1K898

PDB ID(s): None

Isoelectric Point: 4.41

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895