PF3D7_1338700

Genome location: Pf3D7_13_v3:1,561,210..1,563,893(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.96
Trophozoite	not expressed	0.72	0.61
Schizont	possibly expressed	0.68	0.64
Gametocyte	possibly expressed	0.43	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1338700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -2.954 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1352400)

Relative Growth Rate: 0.02 ± 0.07
Confidence: 6.67

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8M0

"Best" AlphaFill ligand hit: B3P (2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol, Local RMSD=5.20) with 2QYU (Global RMSD=15.55)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171488

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	26	18	37
disruptive	13	56	27	73
missense	11	52	25	60

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	57	29	38
disruptive	29	112	69	109
missense	20	97	57	76

PlasmoDB Total SNPs: 92

Non-coding: 54 | Synonymous: 26 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 622 | Molecular Weight (kDa): 73.207

UniProt ID(s): A0A5K1K8M0

PDB ID(s): None

Isoelectric Point: 8.71

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A