PF3D7_1338800

Genome location: Pf3D7_13_v3:1,564,491..1,567,716(-)

Genome classification: Core

Function and Localization

Product Description: CPW-WPC family protein

SignalP Peptide: MNYRFVFLLSVIILNVIQKGCC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0009986	cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.04	0.98
Trophozoite	expressed	0.17	0.90
Schizont	expressed	0.03	0.98
Gametocyte	expressed	1.28	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1338800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.328 | MFS: -3.298 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1352500)

Relative Growth Rate: 1.05 ± 0.16
Confidence: 5.08

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1352500)

Modification: Disrupted | RMgm-3657

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5G0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160751

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	30	17	42
disruptive	9	56	34	82
missense	9	56	33	79

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	66	25	39
disruptive	19	121	66	139
missense	16	105	60	104

PlasmoDB Total SNPs: 195

Non-coding: 167 | Synonymous: 17 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 550 | Molecular Weight (kDa): 64.226

UniProt ID(s): C0H5G0

PDB ID(s): None

Isoelectric Point: 5.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006387	CPW-WPC domain
PFam	PF09717	CPW-WPC domain
Superfamily	N/A	N/A