PF3D7_1339500

Genome location: Pf3D7_13_v3:1,586,916..1,588,336(-)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein L49, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.12	0.92
Schizont	possibly expressed	0.01	0.99
Gametocyte	not expressed	0.07	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1339500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.331 | MFS: -3.794 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9F4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110109

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	0
disruptive	0	0	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 105

Non-coding: 103 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 111 | Molecular Weight (kDa): 13.52

UniProt ID(s): A0A5K1K9F4

PDB ID(s): None

Isoelectric Point: 10.66

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007740	Ribosomal protein L49/IMG2
PFam	PF05046	Ribosomal protein L49/IMG2
Superfamily	N/A	N/A