PF3D7_1339600

Genome location: Pf3D7_13_v3:1,588,075..1,590,380(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.15	0.93
Trophozoite	expressed	0.62	0.66
Schizont	expressed	0.13	0.92
Gametocyte	expressed	0.26	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1339600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.23 | MFS: -2.853 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8W6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532655

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	33	18	47
disruptive	21	86	60	135
missense	17	77	56	125

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	78	29	52
disruptive	52	210	108	207
missense	35	184	92	136

PlasmoDB Total SNPs: 53

Non-coding: 6 | Synonymous: 20 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 592 | Molecular Weight (kDa): 71.607

UniProt ID(s): A0A5K1K8W6

PDB ID(s): None

Isoelectric Point: 9.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A