PF3D7_1339800 (MZT1)

Genome location: Pf3D7_13_v3:1,596,717..1,597,962(-)

Genome classification: Core

Function and Localization

Product Description: mitotic-spindle organizing protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005813	centrosome
Component	GO:0008274	gamma-tubulin ring complex
Component	GO:0031021	interphase microtubule organizing center
Component	GO:0005634	nucleus
Component	GO:0005819	spindle
Process	GO:0051415	microtubule nucleation by interphase microtubule organizing center
Process	GO:0090307	mitotic spindle assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.15	0.90
Schizont	not expressed	0.07	0.95
Gametocyte	not expressed	0.33	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1339800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.279 | MFS: -3.996 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDT7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104170

Most Similar Human Ortholog: Q08AG7

TM-align score: 0.87 | RMSD: 1.26

Seq Identity: 0.37 | Length: 68 / 72

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000204899	mitotic spindle organizing protein 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 119

Non-coding: 116 | Synonymous: 0 | Nonsynonymous: 2 | Stop Codon: 1

Protein Information

Protein Length: 72 | Molecular Weight (kDa): 8.412

UniProt ID(s): Q8IDT7

PDB ID(s): None

Isoelectric Point: 5.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022214	Mitotic-spindle organizing protein 1
PFam	PF12554	Mitotic-spindle organizing protein 1
Superfamily	N/A	N/A