Genome location: Pf3D7_13_v3:1,598,111..1,601,567(+)
Genome classification: Core
Product Description: ABC transporter B family member 5, putative
SignalP Peptide: N/A
# Transmembrane Domains: 4
EC Numbers: 3.6.3.44 (Transferred entry: 7.6.2.2)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005886 | plasma membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | possibly expressed | 0.17 | 0.88 |
| Schizont | not expressed | 0.06 | 0.95 |
| Gametocyte | possibly expressed | 0.22 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1339900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.998 | MFS: -2.39 | #Insertions: 1
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1353300)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1358700)
Modification: Disrupted | RMgm-4777
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K993
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.06) with 3QF4 (Global RMSD=2.44)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.3.44 | xenobiotic-transporting ATPase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 52 | 34 | 59 |
| disruptive | 31 | 126 | 66 | 148 |
| missense | 17 | 99 | 57 | 111 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 103 | 55 | 70 |
| disruptive | 62 | 260 | 108 | 273 |
| missense | 37 | 196 | 82 | 174 |
PlasmoDB Total SNPs: 180
Non-coding: 67 | Synonymous: 62 | Nonsynonymous: 51 | Stop Codon: 0
Protein Length: 925 | Molecular Weight (kDa): 108.512
UniProt ID(s): A0A5K1K993, S5Y618, S5Y640, S5YCM3, S5YCN2, S5YJ44, S5YWJ0, S5YWJ8, S5YWM1, S5YWM6, S5YWN1, S5ZEH3, S5ZEJ0, S5ZEK3
PDB ID(s): None
Isoelectric Point: 8.3
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003439 | ABC transporter-like |
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR011527 | ABC transporter type 1, transmembrane domain |
| InterPro | IPR017871 | ABC transporter, conserved site |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR036640 | ABC transporter type 1, transmembrane domain superfamily |
| InterPro | IPR039421 | Type I protein exporter |
| PFam | PF00005 | ABC transporter-like |
| PFam | PF00664 | ABC transporter type 1, transmembrane domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF90123 | ABC transporter type 1, transmembrane domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 19715599 | Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2,and PfMDR5 at the Plasmodium falciparum plasma membrane. | Kavishe RA, van den Heuvel JM, ..., Koenderink JB | 10.1186/1475-2875-8-205 |
| 28052850 | Association between Polymorphisms in the Pfmdr6 Gene and Ex Vivo Susceptibilityto Quinine in Plasmodium falciparum Parasites from Dakar, Senegal | Gendrot M, Diawara S, ..., Pradines B | 10.1128/AAC.01183-16 |