About Gene List

PF3D7_1340000 (PSOP7)

Genome location: Pf3D7_13_v3:1,601,698..1,603,554(-)

Genome classification: Core

Function and Localization

Product Description: secreted ookinete protein, putative

SignalP Peptide: MKKGFFLVICLCSLILIRTYSA

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020009 microneme
Process GO:0044409 entry into host

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.05 0.97
Trophozoite possibly expressed 0.04 0.97
Schizont possibly expressed 0.02 0.99
Gametocyte expressed 0.07 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1340000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.982 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1353400)

Modification: Tagged | RMgm-112

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8A9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533146

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 30 24 47
disruptive 76 117 68 152
missense 21 88 54 124

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 62 36 48
disruptive 109 235 104 186
missense 35 192 85 133

PlasmoDB Total SNPs: 144

Non-coding: 0 | Synonymous: 44 | Nonsynonymous: 100 | Stop Codon: 0

Protein Information

Protein Length: 618 | Molecular Weight (kDa): 72.243

UniProt ID(s): A0A5K1K8A9

PDB ID(s): None

Isoelectric Point: 9.64

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
18761621 Reverse genetics screen identifies six proteins important for malaria developmentin the mosquito. Ecker A, Bushell ES, Tewari R, Sinden RE 10.1111/j.1365-2958.2008.06407.x
27083421 Identification of three ookinete-specific genes and evaluation of theirtransmission-blocking potentials in Plasmodium berghei Zheng W, Kou X, ..., Cui L 10.1016/j.vaccine.2016.04.011