PF3D7_1340300

Genome location: Pf3D7_13_v3:1,606,863..1,610,503(+)

Genome classification: Core

Function and Localization

Product Description: nucleolar complex protein 2, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030690	Noc1p-Noc2p complex
Component	GO:0030691	Noc2p-Noc3p complex
Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex
Component	GO:0005730	nucleolus
Component	GO:0005654	nucleoplasm
Process	GO:0042273	ribosomal large subunit biogenesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.63	0.33
Trophozoite	expressed	1.07	0.49
Schizont	expressed	0.27	0.85
Gametocyte	expressed	1.01	0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1340300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.185 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDT3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_191724

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	49	34	61
disruptive	31	144	77	186
missense	20	103	62	150

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	100	56	66
disruptive	64	299	142	276
missense	30	219	112	185

PlasmoDB Total SNPs: 200

Non-coding: 53 | Synonymous: 86 | Nonsynonymous: 61 | Stop Codon: 0

Protein Information

Protein Length: 955 | Molecular Weight (kDa): 114.35

UniProt ID(s): Q8IDT3

PDB ID(s): None

Isoelectric Point: 9.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005343	Nucleolar complex protein 2
PFam	PF03715	Nucleolar complex protein 2
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
31384004	Transcriptome-wide dynamics of extensive m(6)A mRNA methylation during Plasmodiumfalciparum blood-stage development.	Baumgarten S, Bryant JM, ..., Scherf A	10.1038/s41564-019-0521-7