PF3D7_1340400

Genome location: Pf3D7_13_v3:1,610,715..1,611,989(-)

Genome classification: Core

Function and Localization

Product Description: ROVER protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.01	1.00
Trophozoite	possibly expressed	0.00	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	expressed	0.03	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1340400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.827 | MFS: -2.528 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1353800)

Relative Growth Rate: 1.03 ± 0.05
Confidence: 7.20

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1353800)

Modification: Tagged | RMgm-5351

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8W7

"Best" AlphaFill ligand hit: HEC (heme c, Local RMSD=0.91) with 3PMQ (Global RMSD=24.74)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532499

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	15	11	22
disruptive	27	53	33	64
missense	23	44	23	56

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	37	17	30
disruptive	43	115	53	116
missense	35	88	42	89

PlasmoDB Total SNPs: 50

Non-coding: 5 | Synonymous: 20 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 385 | Molecular Weight (kDa): 45.216

UniProt ID(s): A0A5K1K8W7

PDB ID(s): None

Isoelectric Point: 9.57

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A