PF3D7_1340500

Genome location: Pf3D7_13_v3:1,613,155..1,616,805(-)

Genome classification: Core

Function and Localization

Product Description: inner centromere protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.18	0.91
Trophozoite	expressed	0.21	0.88
Schizont	expressed	0.18	0.90
Gametocyte	expressed	0.67	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1340500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.41 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8Z6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533375

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	63	43	80
disruptive	49	199	118	235
missense	37	179	107	198

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	141	45	106
disruptive	105	422	200	367
missense	72	343	165	263

PlasmoDB Total SNPs: 127

Non-coding: 0 | Synonymous: 69 | Nonsynonymous: 58 | Stop Codon: 0

Protein Information

Protein Length: 1202 | Molecular Weight (kDa): 146.276

UniProt ID(s): A0A5K1K8Z6

PDB ID(s): None

Isoelectric Point: 10.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005635	Inner centromere protein, ARK-binding domain
PFam	PF03941	Inner centromere protein, ARK-binding domain
Superfamily	N/A	N/A