PF3D7_1340700 (RAB11b)

Genome location: Pf3D7_13_v3:1,620,976..1,623,379(-)

Genome classification: Core

Function and Localization

Product Description: ras-related protein Rab-11B

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.6.5.2 (Small monomeric GTPase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005768	endosome
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	expressed	0.08	0.94
Schizont	expressed	0.06	0.95
Gametocyte	expressed	0.08	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1340700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.91 | MFS: -2.07 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1354100)

Relative Growth Rate: 0.10 ± nan
Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5G2

"Best" AlphaFill ligand hit: GNP (phosphoaminophosphonic acid-guanylate ester, Local RMSD=0.04) with 3LAW (Global RMSD=3.27)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.6.5.2	small monomeric GTPase	GTPGDPEDTAPlexAstatinCCG-977Rap1GapNSC23766CCG-1423Rap1GAP1GTPgammaSCalmodulin...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_117884

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	14	10	15
disruptive	0	6	4	12
missense	0	6	3	10

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	28	11	15
disruptive	0	17	11	48
missense	0	14	9	28

PlasmoDB Total SNPs: 207

Non-coding: 188 | Synonymous: 19 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 229 | Molecular Weight (kDa): 25.931

UniProt ID(s): C0H5G2, Q5F2Q2

PDB ID(s): None

Isoelectric Point: 9.42

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001806	Small GTPase
InterPro	IPR005225	Small GTP-binding protein domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF00071	Small GTPase
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase